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Background : An E670G polymorphism of the exon 12 of the proprotein convertase subtilisin/kexin type 9 ( PCSK9 ) gene was recently found to be associated with increased plasma low-density lipoprotein cholesterol (LDL-C) levels and severity of coronary atherosclerosis. This case-control study tested for a possible link between this  PCSK9  polymorphism and the risk of coronary artery disease (CAD) in an ethnic Chinese population in Taiwan.

clinical chemistry and laboratory medicine

The  PCSK9  gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan