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Background : Polymorphisms of the gene for C-reactive protein (CRP) alter baseline serum CRP concentrations. The impact of polymorphisms of the  CRP  gene (genotype) on the normal range for CRP concentrations (phenotype) has not been determined. This study evaluated the median serum CRP concentrations in normal subjects stratified for  CRP  genotype, after adjustment for relevant covariates as well as polymorphisms in tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) genotypes.

Relationships between C-reactive protein concentration and genotype in healthy volunteers