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Background : Recent studies suggest that the common variant in the glutathione S-transferase ( GST )  M1  ( GSTM1 ) and  T1  ( GSTT1 ) gene is associated with the risk of smoking-related coronary artery disease (CAD). Intra-ethnic as well as inter-ethnic differences are known to impact the frequencies of  GST  gene polymorphisms, thus influencing its interactive effect with tobacco smoking on CAD risk. The aim of the present study was to evaluate the interaction of the genetic polymorphisms of  GSTM1  and  GSTT1  with cigarette smoking and the risk of CAD in a Chinese population.

Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking