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Background : Several factors participate in the pathogenesis of Alzheimer's disease (AD), including free radicals, which when out of balance with their antioxidant capacity contribute to the oxidative stress process and neuronal death. The glutathione S-transferase (GST) polymorphisms are associated with the organism detoxification capacity and can help with the identification of sub-groups that present susceptibility to the development of AD. The aim of this study was to analyze the association of  GSTs , including  GSTP1 ,  GSTT1  and  GSTM1  and apolipoprotein E ( apoE ) with AD and the distribution of these polymorphisms in the first-degree relatives of patients.

clinical chemistry and laboratory medicine

Glutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease: association study and relationship with apolipoprotein E ɛ4 allele