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Background : Polymorphisms of the receptor for advanced glycation end products ( RAGE ) gene have been associated with diabetes, coronary artery disease (CAD) and inflammatory processes. The –374T&gt;A  RAGE  gene promoter polymorphism was shown to affect gene transcription. The aim of this study was to evaluate the association of the –374T&gt;A polymorphism with the severity of CAD in patients with or without type 2 diabetes mellitus.

clinical chemistry and laboratory medicine

The −374 A  allele of the receptor for advanced glycation end products ( RAGE ) gene promoter is a protective factor against cardiovascular lesions in type 2 diabetes mellitus patients