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Background : Treatment with isotretinoin (13-cis - retinoic acid; 13-cis RA) has been associated with hypertriglyceridemia and low levels of high-density lipoprotein (HDL)-cholesterol, which are well-established cardiovascular risk factors. The development of hypertriglyceridemia secondary to this treatment could predispose to the metabolic syndrome. Hence, because of the risk of atherosclerosis associated with this treatment and to help unravel the underlying mechanisms involved, we studied the effect of 13-cis RA on genetic expression in endothelial cells.

Effect of 13-cis-retinoic acid on the genetic expression profile of human umbilical vein endothelial cells (HUVECs) determined by microarray