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Background : Human glutathione S-transferase omega-1 ( hGSTO1 ) has monomethylarsonate (MMA v ) reductase activity. Recent study suggests that two polymorphisms (E155 deletion and E208K) in  hGSTO1  can be related to inter-individual variations in inorganic arsenic metabolism. As useful PCR-based genotyping methods for these  hGSTO1  polymorphisms are not available and data on  hGSTO1  polymorphism in African and Asian populations are insufficient, the aim of the present study was to develop a PCR-based genotyping method for E155del and E208K, and to investigate the allele frequencies of these two polymorphisms in Ovambo and Japanese populations.

clinical chemistry and laboratory medicine

Frequency of two human glutathione-S-transferase omega-1 polymorphisms (E155 deletion and E208K) in Ovambo and Japanese populations using the PCR-based genotyping method