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Background : Choline plays an important role in brain development. Choline-deficient diet (CDD) is known to produce (among other effects) a decrease in acetylcholine in rat brains. The aim of our study was to investigate how CDD administration during gestation and lactation could affect total antioxidant status (TAS) and activities of acetylcholinesterase (AChE), (Na + ,K + )- and Mg 2+ -ATPase in the brains of both male and female newborn and suckling (21-day-old) rats.

clinical chemistry and laboratory medicine

Effects of gestational and lactational choline deprivation on brain antioxidant status, acetylcholinesterase, (Na + ,K + )- and Mg 2+ -ATPase activities in offspring rats