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Background : Reticulocyte-type 15-lipoxygenase-1 (ALOX15) has anti-inflammatory and inflammatory effects and is implicated in the development of asthma, arthritis and atherosclerosis. Previously, we screened the human  ALOX15  gene for variations because genetic variability in  ALOX15  might influence these diseases. We found a C&gt;T substitution at position c.–292 in the  ALOX15  promoter that created a novel binding site for the transcription factor SPI1 and increased  ALOX15  mRNA levels in monocytes from c.–292CT heterozygous volunteers.

The c.–292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective