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Background : The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 ( PPARγ-2 ) gene has been variably associated with insulin resistance, obesity and type 2 diabetes in several populations. However, this association has not been studied in Iranian subjects and we hypothesized that this variation might be associated with insulin resistance, type 2 diabetes and related metabolic traits in this population.

clinical chemistry and laboratory medicine

Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 ( PPARγ-2 ) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population