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Background : Positive test strip results, pathological particles in urine and the presence of proteinuria are common findings in nephropathies. A comparison between these methods and renal biopsies became available with the introduction of quantitative measurement of marker proteins (albumin, transferrin, IgG, α 1 -microglobulin, retinol binding protein, α 2 -macroglobulin, Bence Jones proteins) and standardised urine sediment analysis by flow cytometry or microscopy.

clinical chemistry and laboratory medicine (cclm)

Increased sensitivity in detecting renal impairments by quantitative measurement of marker protein excretion compared to detection of pathological particles in urine sediment analysis