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Background : The single nucleotide polymorphism (SNP) at deoxyribonuclease I (DNase I), designated as  DNASE1  (NCBI SNP number; 1053874), in exon 8 (A2317G) is considered to be one of the susceptibility genes for gastric and colorectal carcinoma and myocardial infarction. Recently, the presence of a variable number of tandem repeat (VNTR) polymorphisms, designated as  HumDN1 , in intron 4 was found.

clinical chemistry and laboratory medicine (cclm)

Frequency of a single nucleotide (A2317G) and 56-bp variable number of tandem repeat polymorphisms within the deoxyribonuclease I gene in five ethnic populations