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Background : Investigation of a 61-year-old Caucasian male suffering from fatigue and weight loss led to the finding of a carbohydrate antigen 19-9 (CA 19-9) concentration of 80kU/L using an ADVIA Centaur analyser. Determination of CA 19-9 on Vidas, AxSYM and Architect i2000 systems gave normal results. His rheumatoid factor concentration was very high (900kIU/L) and assay interference was suspected.

Rheumatoid factor interference in the determination of carbohydrate antigen 19-9 (CA 19-9)