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Background : The low-density lipoprotein receptor-related protein 5 ( LRP5 ) gene has been recently identified as a novel candidate for osteoporosis. The c.4037C&gt;T polymorphism in the  LRP5  gene has been associated with bone mass variance in general population. In contrast, the IVS8+443G&gt;A polymorphism in the vitamin D receptor gene ( VDR ) has not been investigated in relation to bone metabolism. The aim of the present study was to determine  VDR  IVS8+443G&gt;A and  LRP5  c.4037C&gt;T polymorphisms in a cohort of 165 perimenopausal women and to associate the genotypes with biochemical and densitometric bone parameters in a subset of 112 postmenopausal women.

Low-density lipoprotein receptor-related protein 5 and vitamin D receptor gene polymorphisms in relation to vitamin D levels in menopause