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Background : Hyperhomocysteinemia is known to be a risk factor for cardiovascular diseases and is associated with a common mutation in the 5,10-methylenetetrahydrofolate reductase ( MTHFR ) gene (677 C&gt;T). The aims of this study were to confirm: 1) the association between the  MTHFR  C677T mutation and plasma homocysteine (Hcy) levels; 2) the  MTHFR  C677T mutation as a risk factor; 3) the association of the  MTHFR  C677T mutation and plasma B-type natriuretic peptide (BNP) levels; and 4) the correlation between Hcy and BNP levels in cardiovascular diseases.

clinical chemistry and laboratory medicine (cclm)

The methylenetetrahydrofolate reductase C677T gene mutation is associated with hyperhomocysteinemia, cardiovascular disease and plasma B-type natriuretic peptide levels in Korea