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Background : Sialic acid isoforms expressed on glycoconjugates are known to be involved in different biological functions. The aim of this study was to compare α2,3- and/or α2,6-linked sialic acid expression on fibronectin in the seminal plasma of male partners from infertile couples. The data obtained were analyzed in relation to normal and abnormal semen parameters, as well as to fibronectin concentrations.

clinical chemistry and laboratory medicine (cclm)

Lower expression of the α2,3-sialylated fibronectin glycoform and appearance of the asialo-fibronectin glycoform are associated with high concentrations of fibronectin in human seminal plasma with abnormal semen parameters