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Background : The neuroprotein S100 released into the circulation has been suggested as a reliable marker for primary brain damage. However, safe identification of relevant traumatic brain injury (TBI) may possibly be hampered by S100 release from peripheral tissue. The objective of this study was to measure early S100 levels using the Elecsys ®  S100 immunoassay for real-time assessment of severe TBI in multiple trauma.

Significance of Elecsys ® S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients