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Background : There is a need for consensus concerning universal methodological criteria for detection of suboptimal response to acetylsalicylic acid (ASA) therapy. Therefore, animal models to test for ASA effectiveness remain of interest. Our objective was to verify the usefulness of multiparametric whole-blood impedance aggregometry and thromboxane A 2  generation, which are the most popular techniques used for monitoring of ASA treatment effectiveness.

clinical chemistry and laboratory medicine (cclm)

Usefulness of whole blood aggregometry and its comparison with thromboxane generation assay in monitoring acetylsalicylic acid effectiveness – a multiparametric study in rats