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Background : Circulating human thyroglobulin (TG) measurement has a pivotal role in the management of patients affected by differentiated thyroid cancer (DTC). Undetectable thyrotropin (TSH)-stimulated serum TG after thyroid ablation (i.e., thyroidectomy and radioiodine) implies the absence of residual or relapsing DTC. Recently, high-cost recombinant human TSH (rhTSH) was proposed for TG stimulation to avoid uncomfortable thyroxine (T 4 ) withdrawal. However, only a small fraction of relapsing DTC patients showed undetectable TG under T 4  treatment (onT 4 -TG) by high-sensitivity assays. The present study was undertaken to compare onT 4 -TG with the rhTSH-stimulated TG assay (rhTSH-TG),  131 I scanning and neck ultrasound (US) with fine-needle aspiration biopsy.

clinical chemistry and laboratory medicine (cclm)

Thyroglobulin assay during thyroxine treatment in low-risk differentiated thyroid cancer management: comparison with recombinant human thyrotropin-stimulated assay and imaging procedures