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Background : In modern medicine many laboratory measurements are used as a surrogate for clinical outcome. There is therefore a need for models to quantify this approach. The target plot presented here is based on the difference plot. The difference between two measurements is plotted against the initial measurement, of which the first measurement is the index measurement (M index ) and the second the outcome measurement (M outcome ). A vertical line separates normal vs. increased M index  concentrations according to a selected target concentration, and a horizontal line describes the situation of no change. A target line (M target ) with a slope equal to −1 and indicating the selected target concentration is drawn through the crossing point. The six outcome areas thus refer to the combined effect of M index  and M outcome . A target plot taking the biological and analytical variation in consideration is considered.

clinical chemistry and laboratory medicine (cclm)

Clinical outcome estimates based on treatment target limits of laboratory tests: proposal for a plot visualizing effects and differences of medical target setting exemplified by glycemic control in diabetes