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A new quality control model using performance goals based on biological variation in External Quality Assurance Schemes (EQAS) is described. The proposed model aims to use assay (analytical) CV A , bias and total error available from participation in EQAS to describe assay performance using minimum, desirable and optimum quality specifications based on biological variation. The model provides further analysis of EQAS data and should be useful in better management of laboratory quality control, as it provides further information that can facilitate trouble-shooting. Additionally, it can help in evaluating the performance of current and proposed new laboratory methods by applying a unifying system if different EQAS are used to cover a range of analytes.