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This article is intended as a guide for the production of biological reference values of healthy people (physiological reference values) by several clinical laboratories using the same measurement system. This guide is a proposal from the Catalan Association of Clinical Laboratory Sciences to be applied worldwide at a regional level. This guide makes it possible for all clinical laboratories in a region using the same measurement system to adopt the same physiological reference limits. The model presented here is based on the assumption that the production of physiological reference values is a professional task that should be shared by both clinical laboratories and the in vitro diagnostics industry.

clinical chemistry and laboratory medicine (cclm)

Guideline for the production of multicentre physiological reference values using the same measurement system. A proposal of the Catalan Association for Clinical Laboratory Sciences