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A novel statistical approach has recently been described to estimate diagnostic “errors” in method comparison studies. This procedure requires a population-based probability, p p , which describes the spread of values within the population under study, and an analytical probability, p a , quantifying the risk of errors at a decision limit due to replacing one method by the other. The population probability was derived from 207 subjects who were submitted to an oral glucose tolerance test due to suspicion of type 2 diabetes.

clinical chemistry and laboratory medicine (cclm)

The discordance rate, a new concept for combining diagnostic decisions with analytical performance characteristics. 2. Defining analytical goals applied to the diagnosis of type 2 diabetes by blood glucose concentrations