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Allergic asthma is caused by genetic and environmental factors that interact to determine disease susceptibility and severity. Several lines of evidence suggest that the interleukin  (IL)-4  gene and the IL-4-receptor α ( IL-4Rα ) gene are involved in the development of atopic diseases. We sought to determine whether two polymorphism sites in  IL-4  and  IL-4R α chain were associated with allergic asthma in a Chinese population. We obtained DNA and clinical data from allergic asthma patients, which were compared with those of a group of healthy control subjects. The subjects were genotyped for the IL-4 C-590T promoter polymorphism and the IL-4R α chain Q576R by polymerase chain reaction-restriction fragment length polymorphism. The results showed that the IL-4 C-590T was not associated with allergic asthma in a Chinese population. However, the IL-4R α chain 576R/R was significantly increased in allergic asthma patients compared with control subjects (χ 2 =21.16; p &lt; 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R α chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese.

Polymorphisms in the IL-4 and IL-4R [α] Genes and Allergic Asthma