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Method comparison studies are usually evaluated by several statistical tests ( e.g. , regression analysis) which sufficiently describe the analytical (dis)agreement between the results of two procedures. However, they do not provide any information how differences, if observed, influence diagnostic decision making.

clinical chemistry and laboratory medicine

Discordance Rate, a New Concept for Combining Diagnostic Decisions with Analytical Performance Characteristics. 1. Application in Method or Sample System Comparisons and in Defining Decision Limits