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The aim of this study was to determine the effect of  Escherichia coli ( E.coli) -derived lipopolysaccharide on rat plasma low density lipoprotein (LDL), malondialdehyde and 3-nitrotyrosine levels (an indicator of protein nitration). Six hours after intraperitoneal administration of  E.coli , plasma LDL was measured electrophoretically and malondialdehyde level was measured by spectrophotometric method. Plasma malondialdehyde was significantly (p&lt;0.001) elevated in  E.coli -injected rats (4.97 ± 1.33; n=10) in comparison to control animals (1.83 ± 0.5; n=10). In addition, plasma 3-nitrotyrosine level, determined by reversephase HPLC, was also increased in the infected group (2.84 ± 1.17 to 0.22 ± 0.13; n=10). This increase was statistically significant (p&lt;0.001). An increased level of oxidation of lipids and 3-nitrotyrosine was observed as a result of free radical-mediated damage in plasma. In conclusion, asymptomatic infections may increase the risk of atherosclerosis by inducing free radical formation and a consequent increase in the oxidation of LDL.

The Effect of Escherichia Coli-Derived Lipopolysaccharides on Plasma Levels of Malondialdehyde and 3-Nitrotyrosine