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This special issue of the Journal is entirely devoted to the papers delivered at the Second IFCC Roche Conference entitled "Validating and Using Pharmacogenomics" which was held in Kyoto, on the 1619 April 2000. Molecular biology techniques are expected to revolutionise drug discovery and drug treatment. The purpose of these conferences is to highlight the progress in molecular genetics and its potential for therapy and diagnosis. This Conference brought together 200 scientists. There were more than 40 invited speakers, selected oral presentations and 45 posters. In this issue we will present first some general reviews covering the international progress made in the human genome study, the methods used for genotyping and phenotyping and the knowledge on the genes involved in drug metabolism and drug absorption. A second group of papers deals with the stateoftheart in polymorphisms of drug metabolizing enzymes, oxidation enzymes (phase l), conjugation enzymes (phase 2) and transport proteins (phase 3). In a third part we have selected presentations on clinical pharmacology and laboratory medicine (clinical pharmacology, cancer, psychoactive drugs, neurodegenerative diseases). We regret that it was impossible to present the discussions which took place after the presentations, which were also very interesting at this very successful meeting. Some of the presentations will be published later in the Journal CCLM as specific reviews.

The Basis of the Medicine of Tomorrow "Validating and Using Pharmacogenomics" Joint IFCC-Roche Diagnostics Conference, Kyoto, Japan, 1619 April 2000