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Mutations in the Kirsten  ras  2 (K- ras ) gene were described as early events in the process of colorectal carcinogenesis. The aim of this study was to find a possible relationship between the presence of K- ras  mutation in samples of primary colorectal carcinomas and the clinico-pathological data of the investigated patients. Mutation in codon 12 of the K- ras  gene was determined in 18 of 53 colorectal carcinomas (34 %) in our group of patients. The presence of K- ras  gene mutations was not related to gender, age of subject at diagnosis, staging or cancer location (p &gt; 0.05). Sixteen of the 42 (38 %) moderately differentiated carcinomas, and two of the eight (25 %) well differentiated carcinomas contained K- ras  mutation in codon 12, but none of the three poorly differentiated carcinomas contained the mutation. Moderately differentiated tumours contained an aspartate code GAT (in eight cases), a valine code GTT (in six cases), an alanine code GCT (in one case) and a serine code AGT (in one case) in codon 12. Well differentiated tumours contained only the valine code GTT (two cases).

A Relationship between K- ras Gene Mutations and Some Clinical and Histologic Variables in Patients with Primary Colorectal Carcinoma