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Human cystatin C is a low molecular mass protein of  13359 Dalton recently proposed as a new very sensitive marker of changes in  glomerular filtration rate. Serum cystatin C concentration correlates negatively  with glomerular filtration rate as well as or better than creatinine. We  evaluated a recently introduced automated nephelometric immunoassay for cystatin  C in serum or EDTA-plasma samples on the Behring Nephelometer System. The assay  consists of incubating the 100-fold diluted sample for 6 minutes with latex  particles covalently coated with anti-human cystatin C antibodies, and then  quantifying the change of light-scatter produced. Method reproducibility is  satisfactory, the intra-and inter-assay coefficients of variation ranging from  1.58 % to 3.77 % and from 5.6 % to 11.47 % respectively. Rheumatoid factor (≤  1116 IU/ml), bilirubin (≤ 418 μmmol/l), triglycerides (10.47 mmol/l), and  haemoglobin (12 g/l) do not significantly interfere in the assay. No significant  difference was found in cystatin C concentration between serum and EDTA-plasma  samples. Cystatin C is stable in serum samples stored under different conditions  up to one month. This method correlates well (mean difference = −0.536 ± 0.307  mg/l) with another commercially available particle-enhanced turbidimetric  immunoassay. Cystatin C offers better clinical sensitivity than creatinine for  discriminating patients with normal renal function and those with  mild-to-moderate reduction in renal function. This method is suitable for  routine cystatin C measurement, including emergencies.

Quantitative Automated Particle-Enhanced Immunonephelometric Assay for the Routinary Measurement of Human Cystatin C