English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Over a period of three years we determined haptoglobin levels by single radial immunodiffusion (RID) and the haptoglobin phenotype in over 1700 samples of patients suspected of a haemolytic disease. As haptoglobin phenotyping is rather laborious and therefore an expensive method, we re-evaluated the diagnostic need for phenotyping. From our reference values for the respective phenotypes of haptoglobin it may be theoretically argued that phenotyping is still desirable when the RID value is in the range 400-1170 mg/l. Limiting ourselves to suspected haemolytic diseases, one can abolish phenotyping beyond this narrow range without withdrawing important clinical information. From the total group it appeared that 480 samples lay in this range. In 72 samples (15% of 480) the evaluation of the RID values was essentially altered by phenotyping. Careful examination of the medical records indicated that in a number of cases laborious phenotyping had indeed contributed to the diagnosis.

Haptoglobin Typing, is It Clinically Necessary for a Reliable Determination of Haptoglobin with the Single Radial Immunodiffusion Technique?