English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The glycosaminoglycans in human aortae between the 2nd and the 8th decade of age consist chiefly of chondroitin 4-sulfate (20-30%), chondroitin 6-sulfate (20-29%) and heparan sulfate (18-27%), followed by dermatan sulfate (13-17%), hyaluronate (5-15%), keratan sulfate (4-8%) and chondroitin (1-3%). The concentrations of chondroitin 6-sulfate and heparan sulfate decrease from the 2nd to the 8th decade, whereas the concentration and relative proportion of keratan sulfate increase especially from the 6th to the 8th decade. With regard t the longitudinal distributions of the glycosaminoglycans in human aortae the 4th and the 8th decade of age were studied. The total glycosaminoglycan concentration of the younger group exhibits an increase from proximal to distal regions, whereas in the older group the glycosaminoglycan concentration remains nearly constant in all Segments, beirig higher in the aortic arch and lower in the two distal regions than in the corresponding regions of younger aortae. In the region of the aortic arch the concentration and the relative proportion of hyaluronate, dermatan sulfate and chondroitin 4-sulfat decrease on ageing, whereas those of heparan sulfate, keratan sulfate and chondroitin 6-sulfate increase. In the middle region of human aortae only keratan sulfate and chondroitin 4^sulfate increase with age. In the region of the bifurcatio, where the highest deposition of inorganic material has been found, Contents and relative proportions of hyaluronate, Jceratan sulfate and dermatan sulfate iiicrease during ageing, whereas those of heparan sulfate and the chondroitin sulfates, especially chondroitin 6-sulfate, decrease.

Topographic and Age-Dependent Distribution of the Glycosaminoglycans in Human Aorta