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A control mechanism is described, based on a simple proportional/differential regulation. The calculation takes one minute and it takes into account glucose degradation, insulin half life in vivo, and the delay between blood sampling and insulin action on the blood glucose value. This is repeated continuously every minute (short time mode) or every 5 minutes or more (long time mode), depending on the rate of change of the blood glucose. Operator decision is based on digitally converted tables, which are analogous to the graph of proportional control, and on glucose equivalent tables, which give the insulin effect on glucose as a function of time.

Steueralgorithmus für die extrakorporale Blutglucoseregulierung