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This paper, the fourth in a series devoted to the study of the clinical usefulness of estimations of carcino-embryonic antigen (CEA), describes CEA levels in extracts of metastatic breast tumours. --Two groups can be distinguished, with CEA values higher or lower than 1.5 microgram CEA per g protein. The group of tumours with a CEA level  exceeding 1.5 microgram/g (CEA-positive) included a significantly larger percentage or oestrogen receptor-positive tumours than the group with lower CEA levels (CEA-negative). --It is stated that CEA-negative metastases are most likely to be found in patients who fail to respond to hormonal therapy. --No relation was demonstrable between the presence of androgen receptors and the CEA level. All the possible permutations of CEA, oestrogen receptors and androgen receptors were encountered in the tumours examined.

Carcino-Embryonic Antigens, Oestrogen Receptors and Androgen Receptors in Human Breast Tumours. Clinical evaluation of carcino-embryonic antigen, IV