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The serum levels of the mitochondrial enzymes), aspartate transatninase II, malate dehydrogenase II and glutamate dehydrogenase were studied in 82 cases of acute hepatitis. The activity ratio alanine transaminase/glutamate dehydrogenase and the C/M-ratios of aspartate transaminase and malate dehydrogenase were also studied. The serum levels of the mitochondrial en2ymes glutamate dehydrogenase, aspartate transaminase Π and m'alate dehydrogenase II were "per se" useless in defining the severity of acute hepatitis. Conversely, the activity ratio alanine transaminase/glutamate dehydrogenase and the C/M-ratio) of aspartate transaminase proved to be very helpful for this purpose. These cytoplasmic/mitochondrial (C/M) ratios were very high in patients \vho later made a good recovery, while they were surprisingly low in those cases which progressed toward acute liver atrophy.

Serum Cytosolic/Mitochondrial Enzyme Ratio: A Tool for the Estimation of the Severity of Acute Hepatitis