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The intensity and duration of the adrenocortical stimulation^ produced by highly purified natural porcine ACTH (44 U/m/), synthetic ACTH 1—24 peptide (0.44 mg tetracosapeptide/m/) and synthetic ACTH 1—39 peptide (0.4 mg l—39 peptide/m/) with all preparations dissolved in a gelatin solution, \vere investigated in one trial with a total of 18 healthy volunteers. The activity of synthetic ACTH 1—39 peptide significantly exceeds that of the synthetic 1—24 peptide, but is of shorter duration than that of the natural peptide.

Comparative trial with highly purified natural ACTH, synthetic ACTH 1—24 peptide and synthetic ACTH 1—39 peptide