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aCurrent affiliation: Thienpont & Stöckl Wissenschaftliches Consulting GbR, 86643 Rennertshofen (OT Bertoldsheim), Germany. *Corresponding author: Linda M. Thienpont, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium, Phone: +49 8434 94 365 22, E-mail: linda.thienpont@ugent.be Linde A.C. De Grande and Kenneth Goossens: Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium Katleen Van Uytfanghe: Ref4U, Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium Ian Halsall: The Pathology Partnership, Cambridge University Hospitals, Cambridge, UK Jaeduk Yoshimura Noh: Ito Hospital, Tokyo, Japan Koen Hens: Algemeen Medisch Laboratorium (AML), Antwerpen, Belgium Letter to the Editor

Using “big data” to describe the effect of seasonal variation in thyroid-stimulating hormone