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Background:  Structural hemoglobinopathies do not usually have a clinical impact, but they can interfere with the analytical determination of some parameters, such as the glycated hemoglobin in diabetic patients. Thalassemias represent a serious health problem in areas where their incidence is high. The defects in the post-translational modifications produce hyper-unstable hemoglobin that is not detected by most of electrophoretic or chromatographic methods that are available so far.

clinical chemistry and laboratory medicine (cclm)

HB Puerta del Sol [ HBA1 :c.148A&gt;C], HB Valdecilla [ HBA2 :c.3G&gt;T], HB Gran Vía [ HBA2 :c.98T&gt;G], HB Macarena [ HBA2 :c.358C&gt;T] and HB El Retiro [ HBA2 :c.364_366dupGTG]: description of five new hemoglobinopathies