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Background:  Tissue kallikrein and kallikrein-related peptidases (KLKs) compose a family of serine endopeptidases with much clinical interest in oncology, as their potential as diagnostic and/or prognostic molecular biomarkers in several human malignancies has already been evidenced. However, none of the members of this family has ever been studied in hematological malignancies. Based on our preliminary results regarding the differential mRNA expression of several  KLK  genes in peripheral blood mononuclear cells (PBMCs) of patients with chronic lymphocytic leukemia (CLL) compared to healthy blood donors, we decided to study the diagnostic and prognostic potential of  KLK14  mRNA expression in CLL.

clinical chemistry and laboratory medicine (cclm)

mRNA overexpression of kallikrein-related peptidase 14 ( KLK14 ) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients