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Background:  ITPA  polymorphisms have been associated with protection against ribavirin-induced anemia in chronic hepatitis C (HCV) patients. Here we determined the association of inosine triphosphate pyrophosphohydrolase (inosine triphosphatase or ITPase) enzyme activity with  ITPA  genotype in predicting ribavirin-induced anemia.

clinical chemistry and laboratory medicine (cclm)

Inosine triphosphate pyrophosphohydrolase activity: more accurate predictor for ribavirin-induced anemia in hepatitis C infected patients than  ITPA  genotype