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Background:  A  CYP3A5  gene polymorphism is the main determinant of Tacrolimus (Tac) dose requirements among renal transplanted patients. In spite of the utility of  CYP3A5  genotyping to predict the Tac-dose, many patients exhibit an out of range blood Tac level and it is thus likely that other genes/polymorphisms contribute to define Tac bioavailability. To address this issue we searched for coding sequence variants in the  ABCB1 / MDR1  gene in renal transplanted patients treated with Tac and who had out of the range blood levels.

ABCB1 ( MDR-1 ) pharmacogenetics of tacrolimus in renal transplanted patients: a Next Generation Sequencing approach