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Background:  HbA 1c  is a widely used biomarker for the management of diabetes mellitus and can be quantified from blood samples by using various methods, including ion-exchange high-performance liquid chromatography (HPLC), boronate affinity HPLC, and capillary electrophoresis (CE). Here, we evaluated the accuracy of four separation methods for determination of HbA 1c  values in Chinese patients with different hemoglobin disorders.

Erroneous HbA 1c measurements in the presence of β-thalassemia and common Chinese hemoglobin variants