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Background:  Inflammation plays an imperative role in the etiology of cardiovascular diseases (CVD). The role of cytokines in the development and progression of idiopathic dilated cardiomyopathy (IDCM) is still uncertain. The current study was conducted to evaluate the association of tumor necrosis factor-α ( TNF-α ) –238G/A and  IL-6  –572G/C gene polymorphism with IDCM in a Pakistani population.

clinical chemistry and laboratory medicine (cclm)

The tumor necrosis factor-α –238G/A and   IL-6  –572G/C gene polymorphisms and the  risk of idiopathic dilated cardiomyopathy:  a meta-analysis of 25 studies including 9493 cases and 13,971 controls