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Background:  The  HLA-B*58:01  allele is associated with allopurinol-induced severe cutaneous adverse drug reactions (sCADR) in certain geographic regions, but the diversity of the correlation is large. In addition, the currently available  HLA-B*58:01  testing methods are too laborious for use in routine clinical detection. The objective of this study was to develop a new, convenient method for the detection of  HLA-B*58:01  and to investigate the association of  HLA-B*58:01  with allopurinol-induced sCADR in a Han Chinese population.

Detection of HLA-B*58:01 with TaqMan assay and its association with allopurinol-induced sCADR