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Background:  Hyper-methylation of CpG dinucleotides in the promoter region of inhibitor of cyclin-dependent kinase 4A ( INK4A ) has been reported in 60%–80% of hepatocellular carcinoma (HCC). As  INK4A  promoter hypermethylation event occurs early in HCC progression, the quantification of  INK4A  promoter methylation in blood sample may represent a useful biomarker for non-invasive diagnosis and prediction of response to therapy.

Evaluation of INK4A promoter methylation using pyrosequencing and circulating cell-free DNA from patients with hepatocellular carcinoma