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Background:  Ovarian cancer is a lethal gynecological malignancy largely due to the lack of biomarkers for early detection and treatment options. Opioid binding protein/cell adhesion molecule-like gene ( OPCML ) has a tumor-suppressor function in ovarian cancer, and epigenetic inactivation of  OPCML  induces oncogenic transformation of human ovarian surface epithelial cells.

Methylation of OPCML promoter in ovarian cancer tissues predicts poor patient survival