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Background:  Appropriateness of tumor markers (TMs) has been retrospectively studied in limited patients’ series, matching the requests to clinical records. Methods to monitor appropriateness suitable for use on a large scale are required. This study aims to establish and validate an innovative model to estimate appropriateness based on the comparison between the number of TMs requested and the expected requests inferred from epidemiological data.

An epidemiology-based model to estimate the rate of inappropriateness of tumor marker requests