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Background:  Repeated arterial puncture is painful. A mathematical method exists for transforming peripheral venous pH, PCO 2  and PO 2  to arterial eliminating the need for arterial sampling. This study evaluates this method to monitor acid-base and oxygenation during admission for exacerbation of chronic obstructive pulmonary disease (COPD).

Calculating acid-base and oxygenation status during COPD exacerbation using mathematically arterialised venous blood