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Background:  Osteoporosis is a skeletal disorder, characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to increased risk of fracture. Recently, the role of age-related pro-inflammatory cytokines, such as interleukin (IL)-1α, in stimulating bone resorption has been suggested. As osteoporosis has a strong genetic background, the aim of our study was to evaluate the association of two  IL-1α  gene single nucleotide polymorphisms (SNPs) rs2071375 (+12534G&gt;A) and rs17651 (+4845G&gt;T) with osteoporotic phenotypes as well as to find the association with  IL-1α  gene expression in human bone tissue.

Interleukin-1α gene variants influence bone mineral density and the risk of osteoporotic hip fractures in elderly Slovenian people