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Aqueous and organic extracts from  Dictyopteris membranacea  collected from the Tunisian Mediterranean coast were studied for their anti-inflammatory, antioxidant and anti-microbial activities. All extracts had high anti-inflammatory activity in carrageenan-induced rat paw edema assays in Wistar rats, and their effects are comparable to acetylsalicylate lysine (300 mg kg -1 , applied intraperitoneally) used as a reference drug.  Dictyopteris membranacea  extracts had inhibition percentages in the third hour of the assay of 65% at a dose of 100 mg kg -1 , 51% at a dose of 50 mg kg -1 , and 49% at a dose of 100 mg kg -1  in aqueous, chloroform and ethyl acetate extracts, respectively. Chloroform and ethyl acetate extracts exhibited 2,2-diphenyl-1-picrylhydrazyl radical scavenging with IC 50  values (0.089±0.01 and 0.11±0.02 mg ml -1 , respectively) equivalent to the activity of a powerful antioxidant standard, Trolox (IC 50 =0.09±0.02 mg ml -1 ). These extracts (chloroform and ethyl acetate) had reducing activity, and the total phenol contents were: 84.96 and 60.96 mg gallic acid equivalent per gram dried sample, respectively. Organic extracts had moderate antimicrobial activity (using the disc diffusion method) against three bacteria:  Staphylococcus aureus ,  Staphylococcus epidermidis  and  Micrococcus luteus , and four species of a fungal genus:  Candida albicans ,  C. krusei ,  C. dubliniensis  and  C. kefyr  at 10 mg per disc, whereas the aqueous extract exhibited significant antibacterial activity against only  Staphylococcus aureus  and  Listeria monocytogenes .

Anti-inflammatory, antioxidant and antimicrobial activities of aqueous and organic extracts from Dictyopteris membranacea