English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Photoacoustic imaging combines the resolution of ultrasound imaging with the contrast of optical imaging, while maintaining a penetration depth up to a few centimeters. Inorganic gold nanorods can be employed as photoacoustic contrast agents. However, the toxicological properties of such nanoparticles are still under investigation. At the same time, there is an increasing need for clinically established photoacoustic contrast agents. In this paper, therefore, we investigate the photoacoustic properties of Ferucarbotran, which is a clinically established nanoscale contrast agent for magnetic resonance imaging. Gelatin phantoms containing cubes with different gelatin-Ferucarbotran mixture concentrations were prepared and irradiated by a Nd:YAG laser (1064 nm). First, the photoacoustic signals were acquired by a single element ultrasound transducer (7.5 MHz) and evaluated quantitatively. In a second setup, photoacoustic imaging of Ferucarbotran with a modified clinical scanner was demonstrated. The experiments showed that in order to achieve a 6 dB gain of received photoacoustic signal energy, compared to the sensitivity threshold of the used system, a Ferucarbotran concentration of 1.9 μmol Fe/ml is needed. The photoacoustic imaging was successful and showed a contrast-to-background ratio of 15.7 dB for a concentration of 11.63 μmol Fe/ml. However, for imaging in tissue the signal-to-noise ratio has to be increased.

biomedizinische technik

Evaluation of Ferucarbotran (Resovist ® ) as a photoacoustic contrast agent / Evaluation von Ferucarbotran (Resovist ® ) als photoakustisches Kontrastmittel